A miRNA signature predicts benefit from addition of hypoxia-modifying therapy to radiation treatment in invasive bladder cancer.

Br J Cancer · 2021 · PMC8257670 · PMID 33846523

Europe PMC DOI

hedged sentences

0.0008

closest p · 0.0× alpha

0.0740

boldest claim

The sentences

highly significantp = 0.0008actually significant

When categorising based on both signatures, there was a highly significant association with CA9 ( p = 0.0008) and HIF-1α ( p = 0.007) protein expression.

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borderline significantp = 0.06so close (0.05 < p ≤ 0.1)

The interaction between the treatment arms and hypoxia status was borderline significant for LRFS ( p = 0.06) and OS ( p = 0.08).

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borderline significancep = 0.065so close (0.05 < p ≤ 0.1)

Combining the signatures improved performance (HR = 0.26, 95% CI 0.08–0.82, p = 0.014) with borderline significance for an interaction test ( p = 0.065).

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showed a trendp = 0.074so close (0.05 < p ≤ 0.1)

In the TCGA BLCA test data set ( n = 121), the miRNA signature showed a trend for PFS (HR = 1.75, 95% CI 0.94–3.27, p = 0.074) but was not prognostic for OS (HR = 1.53, 95% CI 0.84–2.76, p = 0.16) (Fig. 2b, d and Supplementary Table 6 ).

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