Genetic evidence for a causative effect of airflow obstruction on left ventricular filling: a Mendelian randomisation study.

To assess the relevance of individual SNPs, we performed single SNP MR analyses on each SNP individually and found that 141/253 SNPs shared the direction of the overall MR effect, from which 19/141 were also nominally significant in single SNP MR analyses (P < 0.05; Table 2 and Additional file 2 : Table S3).

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