Single-cell RNAseq and longitudinal proteomic analysis of a novel semi-spontaneous urothelial cancer model reveals tumor cell heterogeneity and pretumoral urine protein alterations.

The transgenic mice reached a humane endpoint within 5–11 weeks of active surveillance after ending carcinogen exposure, while the survival difference among sexes did not reach statistical significance (Median survival: Female: 56 days; Male: 43 days).

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