Although a trend was observed for inhibition of the expression of Pdcd1 , Lag-3 and Ctla4 (genes encoding receptors involved in NFAT-mediated exhaustion) in Nfat -deficient T-ALL, their differential expression in our global transcriptomic analyses did not reach statistical significance.
← all excerpts
NFAT transcription factors are essential and redundant actors for leukemia initiating potential in T-cell acute lymphoblastic leukemia.
1
—
—