showed a trendP = 0.051
IL-6 and CRP were positively associated with high nuclease activity of isolates ( P < 0.001 and P = 0.049, respectively), while S100A8/9 showed a trend ( P = 0.051) indicating that in inflamed airways, S. aureus isolates with high nuclease are selected, thereby presumably facilitating escape from NETs ( 18 , 19 ).