In addition, 94 weeks of data from the RESCUE and REVERSE studies kept showing a better visual trend for the treated eye even though it did not reach statistical significance. 135 , 136 The Efficacy & Safety Study of Bilateral IVT Injection of GS010 in LHON Subjects Due to the ND4 Mutation for up to 1 Year (REFLECT; NCT03293524 ) is the first randomized double-masked placebo-controlled trial evaluating the safety and efficacy of bilateral intravitreal injection of GS010 in patients with LHON with onset within 1 year.
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The Present and Future of Mitochondrial-Based Therapeutics for Eye Disease.
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