PEAβ Triggers Cognitive Decline and Amyloid Burden in a Novel Mouse Model of Alzheimer's Disease.

The latter was highly significant compared to the values of the WT littermates (mixed effects analysis, genotype p < 0.0001, age p < 0.0001, interaction p < 0.0001; Sidak’s post-hoc test 12 m, p = 0.0001).

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For all other lines, exploration times between the novel and familiar object did not reach statistical significance, although there is some trend for more exploration of the novel object ( Figure 7 ).

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