Knockout of Putative Tumor Suppressor Aldh1l1 in Mice Reprograms Metabolism to Accelerate Growth of Tumors in a Diethylnitrosamine (DEN) Model of Liver Carcinogenesis.

The analysis of the Ki-67 proliferation index also suggested enhanced cellular proliferation in the livers of DEN-treated Aldh1l1 −/− mice compared with Aldh1l1 +/+ mice, though the data did not reach statistical significance ( Figure 1 F). 3.2.

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