Exploratory subanalyses evaluating venous and arterial thromboembolism separately revealed that endogenous estradiol genetically predicted by variants in the CYP19A1 gene region was inversely associated with risk of venous thromboembolism (0.74; 95% CI, 0.61-0.90; N = 5475 cases), whereas less-powered association analyses with arterial thromboembolism did not reach statistical significance (0.82; 95% CI, 0.43-1.56; N = 446 cases) (Supplementary Tables 5-7) ( 22 ).
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Association of Genetically Predicted Serum Estradiol With Risk of Thromboembolism in Men: A Mendelian Randomization Study.
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