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COVID-19: Considerations about immune suppression and biologicals at the time of SARS-CoV-2 pandemic.

World J Clin Cases · 2021 · PMC8281435 · PMID 34307589

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A systematic review and meta-analysis conducted on the few available studies so far concluded that patients with immunosuppression and immunodeficiency seem to have a trend toward an increased risk of severe COVID-19 disease; however, the differences did not reach statistical significance[ 5 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.