Although the former approached significance, the remaining features did not show significant differences ( S8A–S8D Fig ), with viral inoculation even in the absence of active replication able to induce lung pathology.
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ACE2-lentiviral transduction enables mouse SARS-CoV-2 infection and mapping of receptor interactions.
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As might be expected, viral RNA levels (measured by RT-qPCR or titer) showed a highly significant correlation with hACE2 RNA expression levels ( S6A and S6B Fig ).