Efficacy and safety of pharmacotherapy for Alzheimer's disease and for behavioural and psychological symptoms of dementia in older patients with moderate and severe functional impairments: a systematic review of controlled trials.

Alzheimers Res Ther · 2021 · PMC8285815 · PMID 34271969

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nearly significantno p-value reported

(2006) found a significant worsening in extrapyramidal symptoms as assessed with the SAS in subjects treated with haloperidol compared with placebo (MD 2.72; 95% CI: [1.36, 4.08]) and a nearly significant difference in the AIMS score compared with placebo (MD 0.58; 95% CI: [− 0.10, 1.26]) [ 64 ].

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