Intravenous administration of LPS activates the kynurenine pathway in healthy male human subjects: a prospective placebo-controlled cross-over trial.

Although the correlation between the maximum increases of CRP and IL-6 after LPS stimulation was highly significant (r = 0.81, p = 0.004), the correlation between the maximum increase in kynurenine/tryptophan and the maximum increase in IL-6 was not significant (r = 0.61, p = 0.06).

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When specifically assessing the association between the maximum increase in inflammatory markers and the maximum increase in ratios after LPS stimulation, only the maximum increase in ratio kynurenine/tryptophan and the maximum increase in CRP showed a nominally significant correlation (r = 0.76, p = 0.01) (Fig. 4 B).

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