Single-nucleus transcriptome analysis of human brain immune response in patients with severe COVID-19.

Genome Med · 2021 · PMC8287557 · PMID 34281603

Europe PMC DOI

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nominally significantP < 0.05actually significant

Nominally significant gene-trait associations ( P < 0.05) from the imputed blood transcriptome were enriched (OR = 1.64, P = 0.030, Fisher’s exact test) with GRNs that are associated with the top 4 microglia TFs (IRF8, ATF5, SPI1, TAL1) (Fig. 4 C).

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