Replication catastrophe induced by cyclic hypoxia leads to increased APOBEC3B activity.

Using TCGA datasets, specifically, Bladder Urothelial Carcinoma (BLCA), Breast Invasive Carcinoma (BRCA), Colorectal Adenocarcinoma (COAD), and Lung Adenocarcinoma (LUAD), a highly significant positive correlation ( P ≤ 0.0001 in 17 cases, P ≤ 0.001 in two cases, P = 0.01 in one case) was found between A3C, A3D, A3F, A3G, A3H and the mean score of the six hypoxia-induced p53-dependent genes in all these cancers (Figure 1J ).

also in 132,142 other papers

A similar pattern of expression was observed for A3C and A3F although this failed to reach statistical significance ( Supplementary Figure S1C, D ).

also in 6,035 other papers