Combinatorial analysis of translation dynamics reveals eIF2 dependence of translation initiation at near-cognate codons.

Nucleic Acids Res · 2021 · PMC8287933 · PMID 34226921

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The translational efficiency of the arsenite-sensitive ORFs was markedly down-regulated by eIF2α KD (Figure 6F ), whereas it was not significantly affected by KO of eIF2A, eIF2D, or both proteins, with the exception of a weakly significant inhibition apparent in eIF2D KO #1 cells ( Supplementary Figure S8 ).

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