Reduced synchroneity of intra-islet Ca²⁺ oscillations in vivo in <i>Robo</i>-deficient β cells.

In our analysis, we saw a trend toward decrease in both C avg and E glob in Robo βKO islets compared to controls though this did not quite reach statistical significance (p=0.05 for both MW ; Figure 4—figure supplement 2F, G ), indicating that Robo βKO islets act less like small world networks than control islets.

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α and δ cells trended towards a higher ratio of homotypic contacts in Robo βKO compared to controls though this did not reach statistical significance (p=0.06) and showed no difference in the level of heterotypic contacts with each other compared to controls ( Figure 1D, E ).

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