Efficacy of Methotrexate on Rat Knee Osteoarthritis Induced by Monosodium Iodoacetate.

J Inflamm Res · 2021 · PMC8289442 · PMID 34290513

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almost significantno p-value reported

Although there was no significant upregulation in the mRNA levels of pro-inflammatory cytokines in the DRG between the two groups, we observed that the upregulated levels of pain-related mRNAs, such as TRPV-1, BDNF, and SP (almost significant) were suppressed by MTX administration.

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showed a trendno p-value reported

Although we did not find the main group effect in lifting behavior, the MTX group showed a trend of increased lifting compared to the vehicle group at week 4, which implies a positive effect of MTX on physical function during OA progression.

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almost significantlyno p-value reported

The upregulation level of SP mRNA (P=0.06) was almost significantly suppressed in the MTX group compared with the vehicle group ( Figure 7 ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.