Trisomy 21-associated increases in chromosomal instability are unmasked by comparing isogenic trisomic/disomic leukocytes from people with mosaic Down syndrome.

A significant increase in the relative proportion of trisomic cells having at least one micronucleus was observed at timepoint 2 compared to timepoint 1 (P = 0.0186), with a marginally significant value being noted for the disomic cells (P = 0.0464) ( Table 3 ).

also in 26,082 other papers

Our longitudinal studies also showed a trend toward decreases in the percentage of trisomic cells at timepoint 2 (compared to timepoint 1) for the majority of our participants, which is an outcome one would predict if cells with chromosomal instability are being eliminated by immune surveillance, or cell-cycle arrested [ 36 ].

also in 53,322 other papers