Genome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal disease.

TSEA and GSEA analyses performed on all 819 transcripts including eQTL genes from FUMA gave rise to similar results although these did not reach statistical significance (not shown). 10.1136/gutjnl-2020-323868.supp7 Supplementary data 10.1136/gutjnl-2020-323868.supp8 Supplementary data Gene expression in HEM tissue and gene-network analyses The expression of HEM genes was studied in integrated mRNA and microRNA Combo-Seq analysis of enlarged haemorrhoidal tissue from 20 patients with HEM and normal specimens from 18 controls (online methods, online supplemental table 1 ).

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