Testicular disposition of clofarabine in rats is dependent on equilibrative nucleoside transporters.

Pharmacol Res Perspect · 2021 · PMC8292784 · PMID 34288585

Europe PMC DOI

hedged sentence

0.1160

closest p · 2.3× alpha

0.1160

boldest claim

The sentences

showed a trendp = .1160not close (p > 0.1)

Rats treated with 10 mg/kg intraperitoneal (IP) injection of the NBMPR prodrug, 6‐nitrobenzylthioinosine 5′‐monophosphate (NBMPR‐P), or vehicle, followed by an intravenous (IV) bolus 10 mg/kg dose of clofarabine, showed a trend toward a lower testis concentration of clofarabine than vehicle (1.81 ± 0.59 vs. 2.65 ± 0.92 ng/mg tissue; p = .1160).

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