Evaluation of SAMP8 Mice as a Model for Sleep-Wake and Rhythm Disturbances Associated with Alzheimer's Disease: Impact of Treatment with the Dual Orexin (Hypocretin) Receptor Antagonist Lemborexant.

Lemborexant induced a significant delay in the acrophase of activity in both SAMR1 and SAMP8 mice, likely by indirectly promoting activity during the ZT 18–24 period, although the increase in activity counts did not reach statistical significance in SAMR1 mice ( Fig. 7C, D ; Supplementary Table 4 ).

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