The influence of brain metastases on the central nervous system effects of methylnaltrexone: a post hoc analysis of 3 randomized, double-blind studies.

Support Care Cancer · 2021 · PMC8295095 · PMID 33629189

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did not reach statistical significanceno p-value reported

In our subset analysis in patients with brain metastases, RFL response at 24 h after the first dose of MNTX was similar but, with an RFL response differential of 20.4%, did not reach statistical significance compared with the placebo group.

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