Drug-associated cues and drug dosage contribute to increased opioid seeking after abstinence.

The correlation for the 0.075 mg/kg heroin dosage was not significant, although a strong trend was observed with discriminative cues in experiment 2 (Pearson correlation, 90 min relapse test vs total heroin intake: Experiment 1: 0.075 mg/kg, Pearson r = 0.395, p = 0.145; 0.03 mg/kg, Pearson r = 0.444, p = 0.026; Experiment 2: 0.075 mg/kg, Person r = 0.489, p = 0.054; 0.03 mg/kg, Pearson r = 0.826, p = 0.00015; 90 min relapse test vs average infusions: Experiment 1: 0.075 mg/kg, Pearson r = 0.279, p = 0.313; 0.03 mg/kg, Pearson r = 0.467, p = 0.019; Experiment 2: 0.075 mg/kg, Pearson r = 0.456, p = 0.076; 0.03 mg/kg, Pearson r = 0.888, p < 0.0001) (Fig. 4 A–H).

also in 5,725 other papers