Vascular endothelial growth factor concentrations in the cerebrospinal fluid of dogs with neoplastic or inflammatory central nervous system disorders.

One study found positive correlations between these parameters in patients with tuberculous meningitis, 74 and another study showed that patients with bacterial meningitis and detectable CSF VEGF concentrations had higher CSF NCC and protein concentrations (although these did not reach statistical significance). 71 However, yet another study found no correlations between CSF VEGF concentrations and conventional CSF parameters in patients with carcinomatous meningitis. 67 The source of VEGF in dogs with inflammatory CNS disease likely involves immune cells, at least in part, but may be multifactorial, and this question requires additional study.

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