The Straw That Broke the Camel's Back: Natural Variations in 17β-Estradiol and COMT-Val158Met Genotype Interact in the Modulation of Model-Free and Model-Based Control.

Further conforming to this pattern, the direct comparison of cycle phases within genotype groups revealed two statistical trends, with the Met-homozygotes showing a slight reduction in avoidance learning capacity [stay frequency non–reward ± SEM: Early = 69.2 ± 4.2%; Late = 76.5 ± 3.8%; t (11) = −2.17, p = 0.052, d = 0.60], while the Val-carriers showed a trend-wise increase in this capability [non-reward stay frequency ± SEM: Early = 74.2 ± 3.0%; Late = 70.4 ± 2.7%; t (28) = 1.73, p = 0.095, d = 0.31] (see Figures 1C,D ).

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