IL-10-Dependent Amelioration of Chronic Inflammatory Disease by Microdose Subcutaneous Delivery of a Prototypic Immunoregulatory Small Molecule.

Results from a pilot experiment using female ApoE -/- mice fed a chow diet that received 4 or 7 rounds of treatment ( Supplementary Figure S6 ) showed a trend but not a significant reduction of plaque area, suggesting that extended exposure to sc microdose curcumin, for at least 8 rounds, is a requirement for significant atheroprotection.

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