Dispersive effects and focused biodistribution of recombinant human hyaluronidase PH20: A locally acting and transiently active permeation enhancer.

PLoS One · 2021 · PMC8297837 · PMID 34292990

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Doses of rHuPH20 from 30 to 3000 U were statistically different from vehicle control ( P <0.05, ANOVA) and showed a trend for increasing dispersion area with rHuPH20 dose, resulting in a mean 2.0-fold increase across this range ( Fig 5A ).

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