Fine-Tuning the PI3K/Akt Signaling Pathway Intensity by Sex and Genotype-Load: Sex-Dependent Homozygotic Threshold for Somatic Growth but Feminization of Anxious Phenotype in Middle-Aged PDK1 K465E Knock-In and Heterozygous Mice.

In that precedent work, magnetic resonance imaging-obtained images or physical sections of fixed organs using the Cavalieri method described reduced brain volume (−20%) but also of metabolic (liver), immune (spleen, −20%), male gonadal (testis, −50%) organs and a slight reduction in kidney size (albeit did not reach statistical significance) in PDK1 −/− mice compared to littermates [ 33 ].

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