The simulations showed a trend (4–6%) for an increased proportion of elderly subjects that had deep sedation and moderate sedation, and a trend for a 4–6% decrease in the proportion of subjects with light sedation and were not sedated, when compared with subjects less than 65 years of age.
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A population pharmacodynamic Markov mixed-effects model for determining remimazolam-induced sedation when co-administered with fentanyl in procedural sedation.
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