The Association between Tau Protein Level in Cerebrospinal Fluid and Cognitive Status: A Large-Scale Analysis of GAAIN Database.

Brain Sci · 2021 · PMC8301769 · PMID 34209512

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

0.0800

boldest claim

The sentences

did not reach statistical significancep < 0.05actually significant

Upregulated genes mapped to 30 distinct KEGG pathways (shown in Table S1 ), and downregulated differentially expressed genes did not reach statistical significance (adjusted p < 0.05) when mapped to any KEGG pathways.

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marginal significancep = 0.08so close (0.05 < p ≤ 0.1)

For the CBAS dataset, a marginal significance ( p = 0.08) was observed for CSF p-tau level between the healthy and dementia groups.

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marginally significantno p-value reported

Statistically significant (or marginally significant) high total tau or p-tau concentrations in CSF were observed in dementia patients compared with healthy people in all datasets.

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