Western blotting demonstrated reduced expression of the a4 (ATP6V0a4) and EII (ATP6V1EII) H + -ATPase subunits whereas the a2 (ATP6V0a2) and A (ATP6V1A) subunits showed a strong trend to be lowered.
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The (pro)renin receptor (ATP6ap2) facilitates receptor-mediated endocytosis and lysosomal function in the renal proximal tubule.
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