a strong trendp = 0.06
Treatment of 2nd trimester (a time when PTB has greater adverse effects on neonatal outcome) placental explants with LPS induced a rapid (4 h) increase in expression of IL-6/8 and TNFα mRNA ( p < 0.05; Figure 2 D,E), as well as a strong trend ( p = 0.06) towards higher expression of the chemokine CCL2 ( Figure 2 B).