Genomics of Endometriosis: From Genome Wide Association Studies to Exome Sequencing.

Worse, in this case, the unadjusted p values were marginally significant (0.004 < p < 0.05) only for three of them (rs2235529-WNT4, rs6907340-LOC100506885, and rs10757272-CDKN2B-AS1).

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In this case, the analysis of concordant SNPs revealed highly significant overlaps, especially for the 1% most significant SNPs together present in Endometriosis and Migraine (85) compared to those that were discordant (43), revealing a 3.61 Odds Ratio compared to the null hypothesis ( p = 7.2 × 10 −4 ).

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It is nevertheless important to notice that except for specific population where strong bottlenecks occurred, the relative risk provided by each risk allele is always less than 1.4, with p -values that are clearly significant due to the quite large number of patients analyzed in each of the studies, this number being even increased by gathering of samples in subsequent meta-analyses.

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