Deficiency of IL-27 Signaling Exacerbates Experimental Autoimmune Uveitis with Elevated Uveitogenic Th1 and Th17 Responses.

We observed that there is a trend of increase of IFN-γ-producing CD4 + T cells in the spleen of IL-27Rα −/− EAU mice when compared to their WT littermates, although it did not reach statistical significance ( Figure 3 A).

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