PlA2 Polymorphism of Platelet Glycoprotein IIb/IIIa and C677T Polymorphism of Methylenetetrahydrofolate Reductase (<i>MTHFR</i>), but Not Factor V Leiden and Prothrombin G20210A Polymorphisms, Are Associated with More Severe Forms of Legg-Calvé-Perthes Disease.

However, a positive trend was observed between LCPD and the presence of factor V Leiden mutation, with the odds ratio of A versus G being 2.9 (95% confidence intervals of 0.2 to 46.9). - G20210A mutation of the prothrombin F2 gene (rs1799963(A)).

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Only for factor V Leiden mutation did we observe a significant trend related to the risk of Perthes disease (odds ratio 2.9; 95% confidence intervals, 0.2–47.8).

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