A Quantitative Pharmacology Model of Exosome-Mediated Drug Efflux and Perturbation-Induced Synergy.

Pharmaceutics · 2021 · PMC8308960 · PMID 34209265

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Results of curve shift analysis showed a trend of increasing synergistic (leftward) shift of C-E curves of OME + PTX or GW + PTX combinations in Donor cells, compared with single agent PTX; the concentration and time thresholds for the shift were 1–5 nM PTX and ≥12 h.

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