Universal Live-Attenuated Influenza Vaccine Candidates Expressing Multiple M2e Epitopes Protect Ferrets against a High-Dose Heterologous Virus Challenge.

Although one out of four and two out of four ferrets in the LAIV and LAIV/NS+4M2e vaccine groups, respectively, demonstrated reduced AUC delta T values, the difference in the mean AUC values relative to the PBS group did not reach statistical significance, most probably due to the low number of animals in each group.

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