Stepwise Conformational Stabilization of a HIV-1 Clade C Consensus Envelope Trimer Immunogen Impacts the Profile of Vaccine-Induced Antibody Responses.

Vaccines (Basel) · 2021 · PMC8310183 · PMID 34358165

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a slight trendno p-value reported

did not reach statistical significanceno p-value reported

Overall, reactivity towards the two different V1V2 subunit proteins was comparable, with a slight trend towards higher reactivity of sera from animals immunized with highly stabilized clade C trimer ConCv5 KIKO trimer (group 5) but also BG505 SOSIP.664 (group 6), which, however, did not reach statistical significance.

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