In vitro cellular and proteome assays identify Wnt pathway and CDKN2A-regulated senescence affected in mesenchymal stem cells from mice after a chronic LD gamma irradiation in utero.

Although this increase was clearly significant (** p = 0.0015), considering that the effect is relatively small and only found at the highest dose point one cannot exclude the possibility that a confounding factor (for instance cell cycle arrest or changes on chromatin architecture) underlies this difference.

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We were then able to show that many highly significant proteins involved in metabolic pathways and the organization of the extracellular matrix (ECM) show different expression 2 years after prenatal exposure.

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