Anti-tumor immunity in mismatch repair-deficient colorectal cancers requires type I IFN-driven CCL5 and CXCL10.

Although it failed to reach statistical significance, we consistently observed that more TILs from dMMR than from CIN donors were recruited into dMMR CRCs, indicating that systemic CD8 + T cells primed by dMMR tumors also have a superior ability to home to CRCs than do those primed by CIN CRCs ( Fig. 3 F ). dMMR CRCs up-regulate T RM markers on infiltrating TILs To better understand the complex interplay between dMMR CRCs and their immune microenvironment, we performed single-cell RNA sequencing (scRNAseq) on orthotopically grown dMMR and CIN CRCs.

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