Cardiovascular Outcome in Patients Treated With SGLT2 Inhibitors for Heart Failure: A Meta-Analysis.

Front Cardiovasc Med · 2021 · PMC8316592 · PMID 34336954

Europe PMC DOI

hedged sentences

0.0400

closest p · 0.8× alpha

0.2400

boldest claim

The sentences

borderline significancep = 0.04actually significant

Dapagliflozin showed borderline significance, obtaining a 29% RRR of death from CV causes (RR = 0.71, 95% CI = 0.52–0.98, p = 0.04, I 2 = 24%) ( Figure 4A ).

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did not reach statistical significancep = 0.24not close (p > 0.1)

Cardiovascular Mortality Although, the direction of the effect was similar for all the tested agents, empagliflozin, canagliflozin, and sotagliflozin did not reach statistical significance for the reduction of CV mortality ( p = 0.24, 0.07, and 0.37, respectively).

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