Right-ventricular dysfunction in HFpEF is linked to altered cardiomyocyte Ca²⁺ homeostasis and myofilament sensitivity.

16 As a result of diastolic dysfunction, filling pressures in ZSF‐1 obese animals were greatly elevated as indicated by an increased E/e′ ratio, and elevated systolic and diastolic LV pressures, whereas relaxation constant tau only showed a trend towards slower relaxation ( Figure 1 B–D ).

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