A clear trend is seen where the highest antibody signals are generated against homosubtypic variants of the immunizing Ag, followed by heterosubtypic variants in the same phylogenetic group, followed by heterosubtypic cross-reactivity for subtypes in the opposite phylogenetic group.
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Administration of Multivalent Influenza Virus Recombinant Hemagglutinin Vaccine in Combination-Adjuvant Elicits Broad Reactivity Beyond the Vaccine Components.
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