a significant trendP < 0.01
As shown in Figure 1 and Supplementary Table 4, miR-20a-5p and miR-122-5p showed a significant trend of up-regulation ( P < 0.01; FC > 1.5) in the serum of CC patients compared with NCs, while miR-133a-3p were conversely down-regulated ( P < 0.01; FC < 0.67).