did not reach statistical significancep = 0.0708
Remarkably, we observed that the ETE 19–1 (Red Pearl) extract showed the strongest anti-aggregation effect, reducing the content of mHTT Q85 -GFP HMW species by nearly 50% (p < 0.05), followed by the ETE 27–1 (South Pearl) with a reduction of HMW species levels around 35%, but this reduction did not reach statistical significance (p = 0.0708) ( Fig 4A and 4B ).