We included the interaction term, “drug difference of anti-HER2 antibody × log(HR) of PFS,” as a covariate in the mixed-effects linear meta-regression analysis of HR for OS, but it did not reach statistical significance in the final mixed-effects linear meta-regression model.
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Anti-HER2 antibody prolongs overall survival disproportionally more than progression-free survival in HER2-Positive metastatic breast cancer patients.
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