The brain injury resulting in neurovascular tissue damage may cause degeneration of the cellular components of NVU and its functional dysregulation with possible excess of endothelin-1, a vasoconstrictor secreted by pericytes and closely related to the development of post traumatic vasospasm.[ 12 , 13 , 18 ] At the same time, the overall number of the brain regions affected by hypoperfusion on D0 did not differ significantly between subgroups of patients with and without vasospasm, while showed a trend to be greater in the former.
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Cerebral vasospasm and hypoperfusion after traumatic brain injury: Combined CT angiography and CT perfusion imaging study.
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