Urine volume tended to increase in Nx-Ob-ZSF1 Vehicle compared to Ln-ZSF1 rats and to further increase in Nx-Ob-ZSF1 FG-2216 rats but these difference did not reach statistical significance ( Fig 3 F ).
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A small-molecule inhibitor of hypoxia-inducible factor prolyl hydroxylase improves obesity, nephropathy and cardiomyopathy in obese ZSF1 rats.
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