Prognostic significance of the albumin-to-globulin ratio for advanced urothelial carcinoma treated with pembrolizumab: a multicenter retrospective study.

Spearman’s rank correlation coefficient showed a strongly significant negative correlation between C-reactive protein and the AGR (ρ = − 0.71, P < 0.01), as well as a weakly significant negative correlation between the NLR and the AGR (ρ = − 0.41, P < 0.01) and a weakly significant positive correlation between hemoglobin and the AGR (ρ = + 0.46, P < 0.01).

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Third, a low AGR may thus more sensitively reflect the degree of poor nutritional status (hypoalbuminemia) and tumor progression (hyperglobulinemia) than either measure alone, and may therefore serve as a highly significant prognostic biomarker 23 .

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